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tgfbr2 s14077  (Thermo Fisher)


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    Thermo Fisher tgfbr2 s14077
    Tgfbr2 S14077, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tgfbr2 s14077/product/Thermo Fisher
    Average 94 stars, based on 15 article reviews
    tgfbr2 s14077 - by Bioz Stars, 2026-02
    94/100 stars

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    Upstream kinase/regulator analyses based on the regulated phosphoproteome data. A, Heatmap of the over-representation p values calculated for each predicted kinase using PhosphoSiteAnalyzer. The subset “serum (−)” indicates SILAC ratio > 2.0, whereas “serum (+)” shows SILAC ratio < 0.5. <t>TGFBR2</t> and ACVR2A/B-specific phosphorylation sites were predicted to be significantly enriched in the “serum (−)” subset (adjusted p value < 0.05). B, Upstream regulator analysis by IPA. The top ten upstream regulators relevant to the regulated phosphoproteome are shown with the corresponding score (−log [p value]). C, IPA-based description of TGF-β1 and the target molecules in our phosphoproteome data. Red indicates increased phosphorylation in serum-free cultured GB2 cells, whereas green shows increased phosphorylation in serum cultured cells. Dashed lines represent indirect interactions caused by TGF-β1.
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    Upstream kinase/regulator analyses based on the regulated phosphoproteome data. A, Heatmap of the over-representation p values calculated for each predicted kinase using PhosphoSiteAnalyzer. The subset “serum (−)” indicates SILAC ratio > 2.0, whereas “serum (+)” shows SILAC ratio < 0.5. TGFBR2 and ACVR2A/B-specific phosphorylation sites were predicted to be significantly enriched in the “serum (−)” subset (adjusted p value < 0.05). B, Upstream regulator analysis by IPA. The top ten upstream regulators relevant to the regulated phosphoproteome are shown with the corresponding score (−log [p value]). C, IPA-based description of TGF-β1 and the target molecules in our phosphoproteome data. Red indicates increased phosphorylation in serum-free cultured GB2 cells, whereas green shows increased phosphorylation in serum cultured cells. Dashed lines represent indirect interactions caused by TGF-β1.

    Journal: Molecular & Cellular Proteomics : MCP

    Article Title: Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals Transforming Growth Factor-beta Receptor type-2 (TGFBR2) as a Novel Regulator of Glioblastoma Stem Cell Properties *

    doi: 10.1074/mcp.M115.049999

    Figure Lengend Snippet: Upstream kinase/regulator analyses based on the regulated phosphoproteome data. A, Heatmap of the over-representation p values calculated for each predicted kinase using PhosphoSiteAnalyzer. The subset “serum (−)” indicates SILAC ratio > 2.0, whereas “serum (+)” shows SILAC ratio < 0.5. TGFBR2 and ACVR2A/B-specific phosphorylation sites were predicted to be significantly enriched in the “serum (−)” subset (adjusted p value < 0.05). B, Upstream regulator analysis by IPA. The top ten upstream regulators relevant to the regulated phosphoproteome are shown with the corresponding score (−log [p value]). C, IPA-based description of TGF-β1 and the target molecules in our phosphoproteome data. Red indicates increased phosphorylation in serum-free cultured GB2 cells, whereas green shows increased phosphorylation in serum cultured cells. Dashed lines represent indirect interactions caused by TGF-β1.

    Article Snippet: TGFBR2 Stealth siRNA (siTGFBR2#1: 5′-CAG AAA UCC UGC AUG AGC AAC UGC A-3′), TGFBR2 Silencer Select Predesigned siRNA (siTGFBR2#2: s14077), and Negative control stealth siRNA with medium GC content were purchased from Life Technologies.

    Techniques: Cell Culture

    Upstream kinase/regulator analyses based on the regulated phosphoproteome data. A, Heatmap of the over-representation p values calculated for each predicted kinase using PhosphoSiteAnalyzer. The subset “serum (−)” indicates SILAC ratio > 2.0, whereas “serum (+)” shows SILAC ratio < 0.5. TGFBR2 and ACVR2A/B-specific phosphorylation sites were predicted to be significantly enriched in the “serum (−)” subset (adjusted p value < 0.05). B, Upstream regulator analysis by IPA. The top ten upstream regulators relevant to the regulated phosphoproteome are shown with the corresponding score (−log [p value]). C, IPA-based description of TGF-β1 and the target molecules in our phosphoproteome data. Red indicates increased phosphorylation in serum-free cultured GB2 cells, whereas green shows increased phosphorylation in serum cultured cells. Dashed lines represent indirect interactions caused by TGF-β1.

    Journal: Molecular & Cellular Proteomics : MCP

    Article Title: Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals Transforming Growth Factor-beta Receptor type-2 (TGFBR2) as a Novel Regulator of Glioblastoma Stem Cell Properties *

    doi: 10.1074/mcp.M115.049999

    Figure Lengend Snippet: Upstream kinase/regulator analyses based on the regulated phosphoproteome data. A, Heatmap of the over-representation p values calculated for each predicted kinase using PhosphoSiteAnalyzer. The subset “serum (−)” indicates SILAC ratio > 2.0, whereas “serum (+)” shows SILAC ratio < 0.5. TGFBR2 and ACVR2A/B-specific phosphorylation sites were predicted to be significantly enriched in the “serum (−)” subset (adjusted p value < 0.05). B, Upstream regulator analysis by IPA. The top ten upstream regulators relevant to the regulated phosphoproteome are shown with the corresponding score (−log [p value]). C, IPA-based description of TGF-β1 and the target molecules in our phosphoproteome data. Red indicates increased phosphorylation in serum-free cultured GB2 cells, whereas green shows increased phosphorylation in serum cultured cells. Dashed lines represent indirect interactions caused by TGF-β1.

    Article Snippet: RNA Interference by siRNA Transfection TGFBR2 Stealth siRNA (siTGFBR2#1: 5′-CAG AAA UCC UGC AUG AGC AAC UGC A-3′), TGFBR2 Silencer Select Predesigned siRNA (siTGFBR2#2: s14077), and Negative control stealth siRNA with medium GC content were purchased from Life Technologies.

    Techniques: Cell Culture